醫(yī)師交流:Nature：抗生素可破壞腸道先天免疫力

日前發(fā)表在英國(guó)《自然》（Nature)周刊上的一篇文章指出，使用抗生素有可能破壞腸道的先天免疫力，這也是引起耐抗生素細(xì)菌感染的原因。

研究人員對(duì)耐抗生素細(xì)菌感染原因進(jìn)行了研究，這是一種廣泛使用抗生素導(dǎo)致的并發(fā)癥，將使住院治療患者的身體健康受到更大的傷害。

研究發(fā)現(xiàn)，盡管抗生素能夠消滅腸道中的很多細(xì)菌，但由抗生素治療引起的腸道先天免疫功能的損傷也為耐抗生素細(xì)菌的繁殖提供了溫床。

研究人員在觀察實(shí)驗(yàn)鼠接受抗生素治療后的反應(yīng)時(shí)，在其體內(nèi)發(fā)現(xiàn)了少量能夠抵抗微生物的腸蛋白R(shí)egⅢ伽馬。這種腸蛋白能夠消滅耐萬(wàn)古霉素腸球菌等高耐抗生素性細(xì)菌。

據(jù)此，科學(xué)家主張研發(fā)能夠提高腸內(nèi)RegⅢ伽馬蛋白含量的療法，以避免因使用抗生素而導(dǎo)致的細(xì)菌感染。（生物谷Bioon。com)

生物谷推薦原始出處：

Nature，doi:10.1038/nature07250，Katharina Brandl, Eric G. Pamer

Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits

Katharina Brandl1,5, George Plitas2, Coralia N. Mihu1,5, Carles Ubeda1, Ting Jia1, Martin Fleisher3, Bernd Schnabl4,5, Ronald P. DeMatteo2 & Eric G. Pamer1,3

Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan-Kettering Institute
Hepatobiliary Service,
Department of Clinical Laboratories, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
Department of Medicine, Columbia University, New York, New York 10032, USA
Present addresses: Department of Genetics, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA (K.B.); Department of Infectious Diseases, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA (C.N.M.); Department of Medicine, University of California San Diego, La Jolla, California 92093, USA (B.S.).

Infection with antibiotic-resistant bacteria, such as vancomycin-resistant Enterococcus (VRE), is a dangerous and costly complication of broad-spectrum antibiotic therapy1, 2. How antibiotic-mediated elimination of commensal bacteria promotes infection by antibiotic-resistant bacteria is a fertile area for speculation with few defined mechanisms. Here we demonstrate that antibiotic treatment of mice notably downregulates intestinal expression of RegIII (also known as Reg3g), a secreted C-type lectin that kills Gram-positive bacteria, including VRE. Downregulation of RegIII markedly decreases in vivo killing of VRE in the intestine of antibiotic-treated mice. Stimulation of intestinal Toll-like receptor 4 by oral administration of lipopolysaccharide re-induces RegIII, thereby boosting innate immune resistance of antibiotic-treated mice against VRE. Compromised mucosal innate immune defence, as induced by broad-spectrum antibiotic therapy, can be corrected by selectively stimulating mucosal epithelial Toll-like receptors, providing a potential therapeutic approach to reduce colonization and infection by antibiotic-resistant microbes.
－－－－－－－－－－－已是常識(shí)了，只是國(guó)人無(wú)知不識(shí)
－－－－－－－－－－－爛用抗菌藥的必然惡果！當(dāng)沒(méi)有了療效確切的抗菌素后西醫(yī)怎么辦？
－－－－－－－－－－－原文鏈接
http://www。nature。com/nature/journal/vaop/ncurrent/full/nature07250.html
－－－－－－－－－－－我在此發(fā)了一篇《抗生素治病還是致��？》的貼子可作參考http://med126。com/forum/viewthread.php?tid=82209
－－－－－－－－－－－抗生素，我嘗過(guò)幾種，味苦至極，當(dāng)為傷陽(yáng)之品。臨床中常見(jiàn)常用擠生素者，反復(fù)感染久治難愈，也許我是純中醫(yī)，西醫(yī)看不好才來(lái)找我，才所見(jiàn)如是。供參考
－－－－－－－－－－－抗生素是廣譜抗菌的藥，可以殺死人體內(nèi)的有害菌，但是人體內(nèi)的有益菌群也會(huì)被殃及。