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醫(yī)學(xué)論文范文:環(huán)氧化酶-2及其選擇性抑制劑塞來(lái)昔布與舌鱗狀細(xì)胞癌侵襲的研究進(jìn)展
【摘要】 環(huán)氧化酶(COX)是致炎物質(zhì)地諾前列酮合成過(guò)程中的重要限速酶。COX-2是環(huán)氧化酶的誘導(dǎo)型，參與炎癥反應(yīng)和腫瘤的發(fā)生。包括舌鱗狀細(xì)胞癌在內(nèi)的大多數(shù)惡性腫瘤均有COX-2的陽(yáng)性表達(dá)。COX-2的活性增強(qiáng)還能提高細(xì)胞與細(xì)胞外基質(zhì)蛋白的黏附能力，增強(qiáng)基質(zhì)金屬蛋白酶的表達(dá)水平，增加腫瘤細(xì)胞的侵襲力。進(jìn)一步研究COX-2選擇性抑制劑塞來(lái)昔布與舌鱗狀細(xì)胞癌侵襲之間的關(guān)系，對(duì)舌鱗狀細(xì)胞癌的治療和預(yù)后有非常重要的意義。
【關(guān)鍵詞】 環(huán)氧化酶; 舌鱗狀細(xì)胞癌; 細(xì)胞侵襲; 塞來(lái)昔布
AResearch progress of cyclo-oxygenase-2 selective inhibitor Celecoxib and the invasiveness of tongue squamous carcinoma HUO Qiu-ju, LI Wei-zhong. (Dept. of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China)
[Abstract] Cyclo-oxygenase(COX) is the major rate-limiting enzyme for the synthesis of prostaglandins. COX-2,which is the inducible form, involved in inflammation and cancer incidence. Study found, COX-2 was overexpressed in the majority of malignant carcinomas including tongue squamous carcinoma. In addition, the increasing activity of COX-2 can improve the adhesion capacity of cells and the extracellular matrix protein, enhance expression level of matrix metalloprotease, and increase the invasion of tumor cells. Further studing the relationship between the cyclo-oxygenase-2 selective inhibitor and tongue squamous carcinoma invasion is very important for tongue cancer treatment and prognosis醫(yī).學(xué)全.在.線(xiàn)網(wǎng)站payment-defi.com醫(yī).學(xué)全.在.線(xiàn)網(wǎng)站payment-defi.com.
[Key words] cyclo-oxygenase; tongue squamous carcinoma; cell invasion; Celecoxib
舌鱗狀細(xì)胞癌(tongue squamous cell cacrci-noma，TSCC)是口腔頜面部最常見(jiàn)的惡性腫瘤之一，早期即可發(fā)生頸部淋巴結(jié)轉(zhuǎn)移。舌鱗狀細(xì)胞癌轉(zhuǎn)移嚴(yán)重影響患者的預(yù)后，也是舌鱗狀細(xì)胞癌患者死亡的重要原因之一。大量的研究資料顯示，環(huán)氧化酶(cyclo-oxygenase，COX)-2通過(guò)多種機(jī)制參與惡性腫瘤的發(fā)生發(fā)展和浸潤(rùn)轉(zhuǎn)移，而其選擇性COX-2抑制劑塞來(lái)昔布對(duì)多種惡性腫瘤的發(fā)生和發(fā)展都有明顯的抑制作用。COX-2在舌鱗狀細(xì)胞癌中呈過(guò)度表達(dá)，其水平明顯高于癌前期病損黏膜和正常上皮。下面就該酶在舌鱗狀細(xì)胞癌侵襲中的作用及其特異性抑制劑塞來(lái)昔布對(duì)舌鱗狀細(xì)胞癌侵襲作用的抑制作一綜述。
